June 19, 2018
“In the study, ddPCR detected PD-L1 mRNAs with a dynamic range of 32–138 copies from plasma. If validated, such a test could offer additional information to physicians who are evaluating an NSCLC patient’s eligibility for anti-PD-L1 therapy.” Read the full story.
April 19, 2018
“These promising initial findings demonstrate the technical feasibility of the PD-L1 circulating blood test as well as the possibility of identifying a meaningful, clinically relevant threshold for the assay. Consequently, Biodesix has combined with collaborators in its physician network, including FirstHealth Moore Regional Hospital and Pinehurst Medical Clinic, to validate the assay by analyzing prospectively ... Read more
March 23, 2018
“In our experience, we have found it beneficial to collect the liquid biopsy at the time of the initial tissue diagnosis if NSCLC is suspected by bedside pathology with rapid onsite evaluation (ROSE). The blood is stored by the company that operates the assay at no cost to the patient or the institution. Once a ... Read more
March 20, 2018
“I see ddPCR as the future of personalized cancer therapies. Based on our cancer center’s successful experience with the technology, I believe it is only a matter of time before these kinds of blood-based liquid biopsies become an indispensable method for doctors to categorize a patient’s disease and determine the best course of treatment.” – ... Read more
February 5, 2018 “Liquid biopsies are becoming more and more accepted, particularly by community physicians seeking timely diagnostic test results to inform treatment decisions. The number of treatment options, especially in certain disease states, like lung cancer, are multiplying rapidly, and the demand for testing that can help physicians determine which patients are most likely to benefit from ... Read more
December 21, 2017 From Clinical Lab Products: “Measurement of PD-L1 is challenging not only when tissue is lacking, but due to the inherent complexity of immunohistochemistry,” says Pritchett. “The testing approach demonstrated in this study shows promise as a method of assessing PD-L1 in plasma. A more objective measure of PD-L1 status could offer a path to better ... Read more
November 30, 2017 “Increasingly, medical oncologists work with multidisciplinary teams to diagnose and manage lung cancer cases. Interventional pulmonologists on these teams perform diagnostic workups, obtain tissue biopsies, and play a role in the timely diagnosis and staging of lung cancer (Ann Am Thorac Soc 2015;12(5):742-751). The number of molecular tests that can impact patient treatment is increasing, while ... Read more
October 23, 2017 CAP Today: “Liquid biopsy is a reality in oncology today. It’s amazing how rapidly it has become the standard of care. And I think pathology labs everywhere are trying to adapt to it and make themselves ready for this new reality.” Read the article.
October 15, 2017
“We can now identify a cancer’s mutations and respond with appropriate therapy without the issues inherent in solid tissue biopsy – not only the delays, but also the intratumoral heterogeneity that is often missed when sampling only one or a few tumor sites.” – Dr. Paul Walker Read the full story.