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Liquid chromatography mass spectrometry

Focuses on quantification of predefined highly-multiplexed sets of proteins with high sensitivity, specificity and reproducibility.

LC-MRM-MS Platform Overview​

Liquid Chromatography Multiple Reaction Monitoring Mass Spectrometry (LC-MRM-MS) is well suited for detection of abundance changes in a large set of proteins in a single analysis. Changes in protein abundance can be used to stratify disease states, optimize therapeutic selection, and determine prognosis.

LC-MRM-MS is ideal for researchers asking, “What happens to my proteins of interest?”

LC-MRM-MS has significant advantages over immunoassays, in particular in multiplexing capability, specificity, and eliminating the need for expensive and time-consuming generation of custom reagents.

Key Benefits of LC-MRM-MS​

icon-sample Flexible Sample Types Blood, tissue or cells
icon-chart Absolute Quantification
icon-target High Precision & Reproducibility​
icon-multitarget Highly Multiplexed Targeted Proteomics​
icon-expences Eliminates Need For Expensive Antibody Development​
icon-clinical-testing Established Clinical Dx Testing

Nodify XL2 Incidental Lung Nodule Test​​

  • Nodify XL2 stratifies patients with incidental lung nodules by risk of malignancy
  • Integrates clinical risk assessment with proteomic insights from a simple blood draw
  • Results support clinical decision-making to efficiently manage incidental nodules
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Lung Cancer Protein Panel​

  • 371 human proteins often found in patients with lung cancer
  • Requires serum, plasma, tissue or cell culture samples
Download Our Lung Cancer Protein Panel

Alzheimer’s Protein Panel​​

  • 356 human proteins often found in patients with Alzheimer’s
  • Requires serum, plasma, tissue or cell culture samples
Download our Alzheimer’s protein panel

Custom LC-MRM-MS Protein Panel​

  • We offer highly-multiplexed custom protein panels and custom assay development for your protein targets of interest.​
  • Experience developing LC-MRM-MS assays with over 1,600 peptides.​
  • No need for expensive and time-consuming antibody development with this approach.

Unbiased DIA LC-MS/MS​

  • Our unbiased (hypothesis-free) proteomic biomarker discovery workflow leverages high-resolution LC-MS/MS to analyze the proteome of large numbers of samples to identify proteins (e.g. peptide biomarkers or targets) that exhibit differential expression between the study groups of interest.
  • Instrumentation and methods are selected to match the goals of each study.

Direct Neoantigen Characterization

  • Directly profile and quantitate MHC-presented peptides with LC-MS.
  • In contrast to in silico peptide sequence prediction models, LC-MS provides direct physical evidence that a peptide is actually present on the cell surface (and therefore amenable to interaction with a TCR).

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