Biodesix® uses highly accurate technologies to analyze circulating cell-free nucleic acids in the blood.

Liquid Biopsy

Identifying genomic drivers and targeting those specific alterations with therapy are a critical aspect of personalized medicine. Traditionally, this has been done through tissue-based mutation testing, but the landscape is evolving rapidly towards less invasive blood-based approaches. Tracking tumor-associated genetic aberrations in the blood can be used to quickly determine whether targeted therapies are a treatment option; assessing the response to therapy, presence of residual disease, recurrence, or relapse; and detecting the emergence of therapy-resistant cancer cells more quickly than conventional tissue-based methods.

THE BENEFITS OF LIQUID BIOPSY

“The standard prognostic procedure for cancer, the tissue biopsy, is woefully inadequate — like trying to gauge a nation’s behaviour by surveying a single street. A biopsy could miss mutations just centimetres away that might radically change a person’s chances for survival. And although biopsies can provide data about specific mutations that might make a tumour vulnerable to targeted therapies, that information is static and bound to become inaccurate as the cancer evolves.”

– ED YONG, “WRITTEN IN BLOOD”, NATURE 2014.

Droplet Digital™ PCR

Biodesix leverages Droplet Digital PCR (ddPCR™) to detect gene mutations in plasma cell-free DNA and RNA. ddPCR is highly sensitive, cost-effective, and has a fast turnaround time. Through the design of custom assays or the use of our on-market GeneStrat® test, Biodesix offers biopharma partners the ability to retrospectively analyze clinical trial samples, prospectively enroll clinical trial patients, and coordinate commercialization.

Next Generation Sequencing

Next Generation Sequencing (NGS) is a high throughput, massively parallel sequencing technique that can generate large amounts of clinically relevant data. Biodesix provides customizable NGS testing services to our biopharma partners for a number of applications, including TMB and MSI, and using a range of specimen types.

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