Platform Overview

Biodesix uses Matrix Assisted Laser Desorption / Ionization Time of Flight (MALDI-ToF) mass spectrometry to interrogate the proteome — including post-translational modifications and splice variants — without the need to identify specific proteins in advance.

Key Benefits of MALDI-ToF MS at Biodesix

BIODESIX’S PROTEOMIC TESTS CAPTURE THE SYSTEMIC
ECOSYSTEM OF A PATIENT BY:

MASS SPECTROMETRY

Taking a biologically agnostic snapshot of the circulating proteome using MALDI-ToF mass spectrometry.

MACHINE LEARNING TEST DESIGN

Converting the acquired molecular data into a clinical test using modern machine learning.

BIOLOGICAL MECHANISM

Interpreting the host’s biology using multiple assessment methods, such as LC-MS and biological pathway protein set scoring.

Host Biology: The Circulating Proteome

Biodesix develops multivariate proteomic tests that can measure protein abundance to gain a real-time comprehensive view of a patient’s changing disease state and immune profile. Blood-based proteomic analyses reflect innate or adaptive immune responses that may affect clinical outcomes on immunotherapy and other treatments.​

OUR MALDI-TOF CLINICAL DIAGNOSTICS​

The VeriStrat®​ Test

• Multivariate test identifies the chronic elevation of acute phase reactants​
• The VeriStrat® test profiles both acute and chronic inflammatory states, which are known to be associated with aggressive cancer

OUR MALDI-TOF PROTEOMIC SOLUTIONS​

ImmunoStrat® Protein Signatures​

Custom Signature Discovery​

  • Biodesix designs custom protein signatures with machine learning to support our partners drug development programs.
  • These tests are designed to help answer specific clinical questions, including selecting patients for immunotherapies, novel therapy combinations, or alternative treatment pathways.

Biological Pathway Protein Set Scoring

  • Biodesix has adapted the well-established methods of gene set enrichment analysis (GSEA) to understand protein pathways that are associated with different serum protein signature test results. ​
  • Pathways include: glycolytic processes, complement system, acute response, wound healing, interleukin-10 and immune response type II.

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