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PROTEOMICS

MALDI-ToF Mass Spectrometry

Top-down proteomics approach for analyzing intact proteins in serum and plasma.

DeepMALDI® Overview

We have developed the DeepMALDI® system, a proprietary high-density matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) mass spectrometry (MS) technology, to help overcome the limitations of conventional MALDI-ToF and other mass spectrometry methods by producing highly sensitive, stable, and reproducible data best suited for the discovery of diagnostic tests with clinical utility.

Key Benefits of DeepMALDI® Mass Spectrometry Analysis​

bdx-tube-icon Minimal Sample Input - as little as 20 μL of serum or plasma
bdx-check-icon High Likelihood of Proteomic Biomarker Discovery
bdx-multiplex-icon Highly Multiplexed & High Throughput
bdx-icon-differentiators-15 Differentiates Splice Variants & PTMs
bdx-target-icon Robust &
Reproducible
bdx-doctor-icon Established Clinical Diagnostic Test (VeriStrat® test)

VeriStrat®​ Test

  • Multivariate test that identifies the chronic elevation of acute phase reactants, which are known to be associated with aggressive cancer
  • Impacts treatment strategy and facilitates disease state monitoring
LEARN MORE ABOUT THE VERISTRAT PROTEOMIC TEST

ImmunoStrat®​ Protein Signatures​

The ImmunoStrat® suite of protein signatures have been designed to interrogate a patient’s circulating proteome with the goal of predicting response to various immunotherapies across multiple tumor types.

Lung Cancer Risk of Recurrence Test

  • We have designed a pre-treatment blood-based protein signature that can identify stage I non-small cell lung cancer patients who have a high-risk of recurrence post-curative resection and may benefit from the addition of adjuvant therapy.
  • This test is currently in development.

Biological Pathway Protein Set Scoring

  • We have adapted the well-established methods of gene set enrichment analysis (GSEA) to understand protein pathways that are associated with different protein signature test results. ​
  • Pathways include: glycolytic processes, complement system, acute response, wound healing, interleukin-10 and immune response type II.

Custom Signature Discovery​

  • We design custom protein signatures with our proprietary AI platform to support our partners drug development programs.
  • These tests are designed to help answer specific clinical questions, including selecting patients for immunotherapies, novel therapy combinations, or alternative treatment pathways.
LEARN MORE ABOUT OUR PROPIETARY AI PLATFORM

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* The images on our site are not representative of the Biodesix lab during COVID-19.